Acquisition of Topical Resistance to Thermal Injury.

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Abstract
A topically acquired indifference of tissue cells towards the action of heat, such as leads to inflammation and necrosis in normal tissues, is descr. This indifference was produced by a mild local pre-irritation of tissues with heat (immersion of a rat paw in 48[degree]C water for 2 min., 15 sec., or of a rabbit ear in 49[degree]C water for 2 min.). Heating was always done under compression of the blood vessels. Local pre-irritation obtained by the injn. of dextran or egg white into the rat paw, or by producing a more chronic inflammation with croton oil applied on the rabbit ear, was ineffective in protecting the tissues locally against a subsequent heat exposure given under compression of the blood vessels. After local pre-irritation of the rat paw by heat, a topical protection was observed also against the inflammatory reaction to intraperit. injd. dextran or egg white and, to a slight degree, to dextran subcutan. injd. into the paw.
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