FACTORS INFLUENCING THE UPTAKE OF [α-14C]AMINOISOBUTYRIC ACID BY RAT TESTES

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Abstract
SUMMARY: The action of various agents on the distribution ratio of [α-14C]aminoisobutyric acid ([14C]AIB) in the testes of adult and growing rats was studied. A decrease in the distribution ratio of [14C]AIB was observed in the testes during maturation. Follicle-stimulating hormone (FSH) administered in vivo to 22-day-old rats or to mature hypophysectomized animals increased the distribution ratio of [14C]AIB in testicular cells. Dibutyryl adenosine 3′: 5′-cyclic phosphate augmented the [14C]AIB uptake into testes of intact or hypophysectomized mature animals. This nucleotide was ineffective in rats under 32 days of age. Testes from mature and immature rats preincubated in vitro with cycloheximide for 1 h showed a decrease in the distribution ratio of [14C]AIB. Cycloheximide also blocked the action of FSH on [14C]AIB uptake in the testes of 22-day-old rats.

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