Reactivity of Ambulatory Blood Pressure to Physical Activity Varies With Time of Day
- 1 April 2006
- journal article
- research article
- Published by Wolters Kluwer Health in Hypertension
- Vol. 47 (4) , 778-784
- https://doi.org/10.1161/01.hyp.0000206421.09642.b5
Abstract
Blood pressure (BP) fluctuates over a 24-hour period, but it is unclear to what extent this variation is governed completely by changes in physical activity. Our aim was to use a BP “reactivity index” to investigate whether the BP response to a given level of physical activity changes during a normal sleep-wake cycle. Hypertensive patients (n=440) underwent simultaneous 24-hour ambulatory BP, heart rate (HR), and activity monitoring. BP and HR were measured every 20 minutes. Actigraphy data were averaged over the 15 minutes that preceded a BP measurement. Individual BP and HR reactivity indices were calculated using least-squares regression for twelve 2-hour periods. These indices were then analyzed for time-of-day differences using a general linear model. Systolic BP and HR were generally more reactive to physical activity than diastolic BP. The highest reactivity of systolic BP (mean±SE=4±1 mm Hg per logged unit change in activity) was observed between 8:00 am and 10:00 am (P=0.014). Between 10:00 am an...Keywords
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