LYMPHOCYTOTOXIC ANTI-LEWISbH ANTIBODY

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Abstract
We wish to report strong lymphocyte crossmatch incompatability attributable to anti-Lea antibody. The prospective renal transplant recipient was Le(a-b-) and her serum contained potent anti-Lea and anti-LebH antibodies. Despite the fact that we were able to demonstrate greater B lymphocyte than T lymphocyte Lewis(a+) an-tigenicity, this serum was capable of causing greater than 80% cytotoxicity of Le(a+) and Le(b+)O or A2 whole lymphocyte populations. Antibody activity was completely inhibited by Lewis substance. This inhibition was specific and did not interfere with HLA antibody activity.