Effect of insulin and poisons on glucose uptake of sheep and goat placenta
- 1 January 1961
- journal article
- research article
- Published by American Physiological Society in American Journal of Physiology-Legacy Content
- Vol. 200 (1) , 64-66
- https://doi.org/10.1152/ajplegacy.1961.200.1.64
Abstract
The basal glucose uptake of the cotyledons of sheep and goats was found to be 1.44 ± 0.09 mg/gm/hr.; that of the fetal chorion to be 2.22 ± 0.11; and that of the maternal uterine mucosa to be 2.05 ± 0.16 mg/gm of tissue/hr. The tissue was obtained from pregnant animals between 45 and 55 days gestation. Insulin, at a concentration of 100 mu/ml, has no effect on net glucose utilization of any of these tissues. Nitrogen and cyanide both increased the basal uptake of cotyledons by approximately 70%. Phlorizin was shown to inhibit both the basal uptake of glucose and the cyanide-accelerated uptake of glucose.Keywords
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