Adenomatous polyposis coli and multiple endocrine neoplasia type 2b. A pathogenetic relationship
- 15 January 1985
- Vol. 55 (2) , 375-381
- https://doi.org/10.1002/1097-0142(19850115)55:2<375::aid-cncr2820550214>3.0.co;2-y
Abstract
A young man presenting with Cushing's syndrome was found to have multiple endocrine neoplasia type 2b MEN 2b and adenomatous colonic polyposis with duodenal and gastric polyps. The entire syndrome of MEN 2b was present, including metastatic medullary carcinoma of the thyroid, a pheochromocytoma, and peripheral nerve abnormalities. The concurrence of these two inherited multiple neoplasia syndromes may reflect a common pathogenetic step in this patient.This publication has 50 references indexed in Scilit:
- Gardner's syndromeDigestive Diseases and Sciences, 1980
- Chemical transformation of cultured human skin fibroblasts derived from individuals with hereditary adenomatosis of the colon and rectumInternational Journal of Cancer, 1980
- TETRAPLOID FIBROBLASTS AND FAMILIAL POLYPOSIS COLIThe Lancet, 1980
- Natural History of Familial Medullary Thyroid CarcinomaNew England Journal of Medicine, 1978
- Penetrance and expressivity of the gene responsible for the Gardner syndromeClinical Genetics, 1977
- Medullary carcinoma of the thyroid glandCancer, 1975
- Mutation and Cancer: Statistical Study of RetinoblastomaProceedings of the National Academy of Sciences, 1971
- Thyroid carcinoma and Cushing's syndromeJournal of Clinical Pathology, 1968
- PROSTAGLANDIN SECRETION BY MEDULLARY CARCINOMA OF THE THYROID: A Possible Cause of the Associated DiarrhoeaThe Lancet, 1968
- LOCALIZATION OF ANTIGEN IN TISSUE CELLSThe Journal of Experimental Medicine, 1950