Alkylation of DNA by Organophosphorus Pesticides
- 1 November 1981
- journal article
- Published by Wiley in Acta Pharmacologica et Toxicologica
- Vol. 49 (s5) , 51-55
- https://doi.org/10.1111/j.1600-0773.1981.tb03252.x
Abstract
Methods for the detection of in vivo alkylation of nucleic acids are discussed. Alkylation of mammalian DNA at N-7 of guanine provides the most sensitive and least equivocal evidence of methylation by an exogenous chemical or its metabolite. No 7-methylguanine was detected in the combined DNA from the lungs, livers, hearts, brains, kidneys, testes and spleens from 20 rats exposed to 0.064 micrograms l-1 of [Me-14C]-dichlorvos at a specific radioactivity of 113 Ci mol-1 for 12 hrs.Keywords
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