Calcitonin gene‐related peptide desensitizes skeletal muscle arterioles to substance P in vivo
Open Access
- 1 November 1988
- journal article
- research article
- Published by Wiley in British Journal of Pharmacology
- Vol. 95 (3) , 673-674
- https://doi.org/10.1111/j.1476-5381.1988.tb11691.x
Abstract
Calcitonin gene‐related peptide (CGRP) was tested for possible interactions with the effects of substance P on rabbit skeletal muscle arterioles in vivo. Both CGRP and substance P dose‐dependently increased arteriolar diameter. However, pretreatment with CGRP made the arterioles insensitive to substance P, and also prevented the formation of aggregates of leukocytes and platelets normally seen after substance P. These results suggest that CGRP, in addition to its direct effects, may act as a modulator of the effects of substance P in neurogenic inflammation.This publication has 7 references indexed in Scilit:
- Substance P and calcitonin gene-related peptide: immunohistochemical localisation and microvascular effects in rabbit skeletal muscleNaunyn-Schmiedebergs Archiv für experimentelle Pathologie und Pharmakologie, 1987
- Vasodilatory effects and coexistence of calcitonin gene‐related peptide (CGRP) and substance P in sensory nerves of cat dental pulpActa Physiologica Scandinavica, 1987
- NeuroimmunologyPublished by Elsevier ,1986
- Calcitonin gene-related peptide is a potent inhibitor of substance P degradationEuropean Journal of Pharmacology, 1985
- Calcitonin gene-related peptide is a potent vasodilatorNature, 1985
- Sir Thomas Lewis's nocifensor system, histamine and substance-P-containing primary afferent nervesTrends in Neurosciences, 1983
- Blood flow in the rabbit tenuissimus muscle Influence of preparative procedures for intravital microscopic observationActa Physiologica Scandinavica, 1982