Characteristic immunocytochemical localization of glutathione-peroxidase (GSH-PO) in rat testicular interstitial macrophages.

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Abstract
An immunohistocytochemical localization of glutathione-peroxidase (GSH-PO) in rat testicular interstitial macrophages was studied on: normal untreated rats; hypophysectomized rats 2 wk after surgery; and rats treated with gonadotropin for 1 wk after hypophysectomy. In the untreated rats GSH-PO was observed in cytosol as a characteristic lysosome-like structure. In the hypophysectomized rats the number of GSH-PO positive macrophages was decreased as compared with that of the controls. However, in rats given gonadotropin the number of GSH-PO positive macrophages increased as compared with that of group 2. An intracellular lysosome-like GSH-PO also increased as compared with that of the other groups. These findings suggest that a very close relationship lies between immunocytochemical localization of GSH-PO in the testicular interstitial macrophages and testosterone production in the testicular Leydig cells. The possible role of GSH-PO in the testicular interstitial macrophage is discussed.

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