"Augmented" Gastric Analysis

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Abstract
GASTRIC ANALYSES based on maximal stimulation with histamine (beta-imidazolyethyl-amine) or betazole hydrochloride (Histalog) are becoming more popular in evaluating acid secretion. Potentially dangerous side effects can occur with the augmented doses of these drugs even with the combined use of antihistamine drugs. Histamine as a gastric acid stimulus was originally used in a dose of 0.01 mg/kg of body weight of histamine acid phosphate.1With this dose the only reported side effects have been flushing, headache, and occasional mild, transient hypotension.2 Kay, in 1953, demonstrated that increasing the dose of histamine acid phosphate from 0.01 mg/kg of body weight to 0.04 mg/kg resulted in a progressive increase of the gastric acid output.3Because this dose was felt to represent "maximal" stimulation, the augmented histamine response formed the basis of a test of gastric acid secretion, which has increased in popularity. In the original work with the higher

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