The role of U5 snRNP in pre-mRNA splicing
Open Access
- 1 October 1997
- journal article
- review article
- Published by Springer Nature in The EMBO Journal
- Vol. 16 (19) , 5797-5800
- https://doi.org/10.1093/emboj/16.19.5797
Abstract
The current model for the function of the U5 small nuclear ribonucleoprotein particle (snRNP) in the spliceosome proposes that U5 carries binding sites for the 5′ and 3′ exons, allowing the spliceosome to ‘tether’ the 5′ exon intermediate produced by the first catalytic step and align it with the 3′ exon for the second step. Functional analysis of U5 snRNA in cis ‐spliceosomes has provided support for this model, and data from nematode and trypanosome splicing systems suggest that U5 or a U5‐like snRNA performs a similar role in trans ‐splicing.Keywords
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