Haematopoietic cell-fate decisions, chromatin regulation and ikaros
- 1 March 2002
- journal article
- review article
- Published by Springer Nature in Nature Reviews Immunology
- Vol. 2 (3) , 162-174
- https://doi.org/10.1038/nri747
Abstract
The regulated production of several terminally differentiated cell types of the blood and immune systems (haematopoiesis) has been the focus of many studies on cell-fate determination. Chromatin and the control of its structure have been implicated in the regulation of cell-fate decisions and in the maintenance of the determined states. Here, I review advances in the field, emphasizing the potential role of chromatin in lineage commitment and differentiation. In this context, I discuss Ikaros, an essential regulator of lymphocyte development and an integral component of a functionally diverse chromatin remodelling network that operates from the early stages of haematopoiesis to the mature lymphocytes.Keywords
This publication has 100 references indexed in Scilit:
- Unconventional Potentiation of Gene Expression by IkarosJournal of Biological Chemistry, 2002
- Ikaros, a Lymphoid-Cell-Specific Transcription Factor, Contributes to the Leukemogenic Phenotype of a Mink Cell Focus-Inducing Murine Leukemia VirusJournal of Virology, 2002
- Correlation Between Histone Lysine Methylation and Developmental Changes at the Chicken β-Globin LocusScience, 2001
- Transitions in Distinct Histone H3 Methylation Patterns at the Heterochromatin Domain BoundariesScience, 2001
- Translating the Histone CodeScience, 2001
- Methylation of Histone H4 at Arginine 3 Facilitating Transcriptional Activation by Nuclear Hormone ReceptorScience, 2001
- Down-regulation of TDT transcription in CD4+CD8+thymocytes by Ikaros proteins in direct competition with an Ets activatorGenes & Development, 2001
- A Role for Histone Acetylation in the Developmental Regulation of V(D)J RecombinationScience, 2000
- Control of Chromatin RemodelingCritical Reviews™ in Eukaryotic Gene Expression, 2000
- The “Dark Side” of Chromatin RemodelingCell, 1999