A Basic Problem--The Measurement of Height and Area

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Abstract
In chromatograms arising in different situations, it may be that peak freight or peak area is the mort fundamental measure of sample composition. Examples illustrate this. There need to be facilities to evaluate either measure. Evaluation of peak heights and areas as carried out by digital computers and microprocessor is described. Methods for signal filtering and outlier rejection that art pertinent to chromatogram interpretation art discussed. The process of recognizing baseline segments and chromatogram peaks is presented along with subsequent calculations of components' net response peak heights and areas. Resolution of overlapped chromatogram peaks is illustrated graphically. It is shown why tangent skimming normally introduces more error than dropping a perpendicular and in what cases it is an improvement. Emphasis is on describing the variety of situations with which a computer has to deal in interpreting chromatograms. It is argued that in certain cases the best it can do is present the results of its alternate interpretations graphically to a human and ask for help.

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