The Role of Oligosaccharides in Modifying Protein Function
- 28 September 2007
- book chapter
- Published by Wiley
- Vol. 145, 241-256
- https://doi.org/10.1002/9780470513828.ch14
Abstract
It has been proposed that protein-bound oligosaccharides interact with the protein to which they are attached to up- or down-regulate the bioactivity of the 'composite' glycoprotein. Oligosaccharide analyses of the glycoproteins Thy-1, tissue plasminogen activator and immunoglobulin G are presented. Correlations between particular glycoforms and enzymic activities are demonstrated for tissue plasminogen activator. The change in the prevalence of particular immunoglobulin G glycoforms is shown to correlate with disease activity in rheumatoid activity.Keywords
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