Association of class I major histocompatibility heavy and light chains induced by viral peptides
- 1 August 1989
- journal article
- Published by Springer Nature in Nature
- Vol. 340 (6233) , 443-448
- https://doi.org/10.1038/340443a0
Abstract
We describe a cell in which association of a major histocompatibility complex class I heavy chain with beta 2-microglobulin is induced by a peptide derived from influenza nucleoprotein. Association of antigenic peptides with the binding site of class I molecules may be required for correct folding of the heavy chain, association with beta 2-microglobulin and transport of the antigen-MHC complex to the cell surface.Keywords
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