EXPERIMENTAL ALIMENTARY TOXIC ALEUKIA IN CATS

  • 1 January 1981
    • journal article
    • research article
    • Vol. 31  (1) , 43-47
Abstract
T-2 toxin [trichothecin] was given orally to cats every other day to evaluate the suitability of this speices as a model for the human disease, alimentary toxic aleukia. Chronic lethal intoxication was characterized by pancytopenia, hemorrhagic diatheses, bone marrow aplasia, diminished hemostatis, severe lymphatic tissue alterations and histopathologic changes in proliferative tissue. Clinical signs included vomiting, bloody feces, weakness, lassitude, ataxia, dyspnea, dehydration, weight loss and pre-terminal anorexia. Clinical course, hematologic picture and gross and microscopic tissue changes seen in experimentally produced disease in cats were similar to alimentary toxic aleukia, a frequently fatal mycotoxin-induced disease of man.

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