Serotonergic and adrenergic receptors in alcohol-preferring and non-preferring rats
- 1 October 1988
- journal article
- conference paper
- Published by Springer Nature in Journal Of Neural Transmission-Parkinsons Disease and Dementia Section
- Vol. 71 (3) , 207-218
- https://doi.org/10.1007/bf01245714
Abstract
Serotonergic and adrenergic receptors in brain areas of the alcohol-preferring P and alcohol-nonpreferring NP rats were compared by radioligand-binding assays. Binding of3H-serotonin (3H-5HT) to 5HT-1 receptors in membranes of cerebral cortex and hippocampus was significantly higher in density (B max values) and affinity (Kd values) in the P than in the NP rats, whereas B max values in membranes from the brain stem of the P rats were lower than those of the NP rats. No significant difference between the P and NP lines was observed when the binding of3H-ketanserin to 5HT-2 receptors and of3H-WB4101,3H-clonidine and3H-dihydoalprenolol to α-1, α-2 and β-adrenergic receptors was compared. The increase of3H-5HT binding probably indicates up-regulation or supersensitivity of 5HT-1 receptors as a compensatory mechanism to the lower levels of 5HT in brain areas of the P rats (Murphy, et al., 1982).This publication has 36 references indexed in Scilit:
- Adaptive changes in the 5-HT2 binding site after chronic administration of agonists and antagonistsNeuropharmacology, 1986
- Chronic effects of fluoxetine, a selective inhibitor of serotonin uptake, on neurotransmitter receptorsJournal Of Neural Transmission-Parkinsons Disease and Dementia Section, 1985
- Effect of destruction of central noradrenergic and serotonergic nerve terminals by systemic neurotoxins on the long-term effects of antidepressants on?-adrenoceptors and 5-HT2 binding sites in the rat cerebral cortexJournal Of Neural Transmission-Parkinsons Disease and Dementia Section, 1984
- Manipulations of synaptic serotonin: Discrepancy of effects on serotonin S1 and S2 sitesLife Sciences, 1983
- Chronic antidepressant treatment and central 5-HT synapsesNeuropharmacology, 1983
- Effect of methiothepin on imipramine- or mianserin-induced subsensitivity of serotonergic receptorsLife Sciences, 1982
- Regional brain levels of monoamines in alcohol-preferring and -nonpreferring lines of ratsPharmacology Biochemistry and Behavior, 1982
- Blockade of 5-HTP reduction of ethanol drinking with the decarboxylase inhibitor, Ro 4-4602Pharmacology Biochemistry and Behavior, 1981
- Progress toward a voluntary oral consumption model of alcoholismDrug and Alcohol Dependence, 1979
- THE ROLE OF CEREBRAL SEROTONIN IN THE ETHANOL PREFERENCE OF ANIMALSAnnals of the New York Academy of Sciences, 1973