Effect of Pantothenate Deficiency on Synthesis of Adrenal Cholesterol Following Stress.

Publisher Website
Google Scholar
Abstract
Male rats 40 days of age were given either a diet deficient in pantothenic acid or a normal diet. After 30 days on the diets, the rats were unilaterally adrenalectomized and the adrenal cholesterol detd. At intervals varying from 6 hrs. to 7 days, the remaining adrenal was removed for cholesterol detn. At the time of unilateral adrenalectomy, the adrenal cholesterol of the deficient rats was significantly lower than that of control animals on the normal diet. After the stress of unilateral adrenalectomy, the cholesterol content of the remaining adrenal decreased immediately in both diet groups. By 24 hrs. after unilateral adrenalectomy, the adrenal cholesterol of the normal rats had returned to its initial value; in the deficient rats adrenal cholesterol remained depressed up to 7 days after the stress. Probably the synthesis of adrenal cholesterol is decreased in pantothenate deficiency.