Stimulation of Feeding in Rats by Intraperitoneal Injection of Antibodies to Glucagon
- 26 November 1982
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 218 (4575) , 894-896
- https://doi.org/10.1126/science.7134979
Abstract
Intraperitoneal injections of antibodies to pancreatic glucagon at the onset of the first meal after 12 hours of food deprivation increased meal size 63 percent and meal duration 74 percent in rats. The antibodies also reduced the increase in hepatic vein blood glucose that occurred during meals in control rats, but did not affect the prandial increase in portal vein blood glucose. These results suggest that, under these conditions, pancreatic glucagon is necessary for the normal termination of meals.This publication has 27 references indexed in Scilit:
- Subject Index Vol. 17, Suppl. 1, 2004Cerebrovascular Diseases, 2003
- Pancreatic glucagon fails to inhibit sham feeding in the ratPeptides, 1982
- Pancreatic glucagon and postprandial satiety in the ratPhysiology & Behavior, 1982
- Neutralization of Glucagon by Antiserum as a Tool in Glucagon PhysiologyJournal of Clinical Investigation, 1978
- Insulin and glucagon as determinants of body weight set point and microregulation in rats.Journal of Comparative and Physiological Psychology, 1978
- Extrapancreatic GlucagonsDigestion, 1978
- The influence of glucagon on hepatic glycogen mobilization in exercising ratsPflügers Archiv - European Journal of Physiology, 1976
- The effect of glucagon antibodies on plasma glucose and insulin levelsBiochimica et Biophysica Acta (BBA) - General Subjects, 1973
- Cholecystokinin decreases food intake in rats.Journal of Comparative and Physiological Psychology, 1973
- Studies on the Administration of Glucagon and Insulin Antibodies to RatsHormone and Metabolic Research, 1973