Bupivacaine (Marcaine®): An Evaluation of its Tissue and Systemic Toxicity in Humans
- 1 April 1977
- journal article
- research article
- Published by Wiley in Acta Anaesthesiologica Scandinavica
- Vol. 21 (2) , 109-121
- https://doi.org/10.1111/j.1399-6576.1977.tb01201.x
Abstract
In countries other than the U.S.A., dosages of bupivacaine have been limited to 100 mg without epinephrine and 150 mg with epinephrine. A review of 7,688 regional block procedures employing bupivacaine in concentrations of 0.25, 0.5, and 0.75%, and in dosages as high as 600 mg, indicated that such stringent restrictions: (1) are unwarranted, (2) make comparisons with other local anesthetic agents difficult, and (3) are in need of revision.Keywords
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