Lipid Requirement for μ Opioid Receptor Binding
- 5 October 1987
- journal article
- research article
- Published by Wiley in Journal of Neurochemistry
- Vol. 49 (4) , 1007-1012
- https://doi.org/10.1111/j.1471-4159.1987.tb09987.x
Abstract
We have previously shown that a partially purified μ opioid receptor from bovine brain requires lipids to exhibit full binding activity. In the present report, we have determined the specificity of this lipid requirement. Lipids active in this regard were found always to contain an acidic head group and a fatty acid with two or more double bonds. Free, polyunsaturated fatty acids were also able to confer high binding activity on the partially purified opioid receptor. The possible roles lipids play in opioid binding are discussed in light of these data.Keywords
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