METABOLIC CHANGES IN SHOCK AFTER BURNS

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Abstract
Scalds were produced in white o rats of standard size by immersion in hot water at constant temps. for definite periods of time. The following effects of the burns were recorded: The plasma amino N rose in all cases, slightly after burns at 70[degree]C, 5 secs., markedly after burns at 80[degree]C., 7 secs. The increase was progressive within the time limits studied (12 hrs.). The free amino nitrogen level of the livers was higher in burned than in normal rats. The ammonia level of the blood was increased in burned rats, while there was very little change in the ammonia or amide content of the livers. The rate of respiration of slices from the livers of scalded rats was not significantly different from normal. The adrenal total cholesterol fell to as low as 1/5 of the control value when measured as mg. % of adrenal wt. The decrease was definite after mild, as well as after severe, scalds. There was no change in adrenal weight. The intraperit. injn. of adrenal cortical extract or of saline alcohol soln. reduced somewhat the decrease in adrenal cholesterol. Hypophysectomy done 3 days before the scalding entirely prevented the usual fall in adrenal total cholesterol following the scalds.

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