Synthesis of optically active azetidine-2,4-dicarboxylic acid and related chiral auxiliaries for asymmetric synthesis
- 1 January 1995
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Perkin Transactions 1
- No. 6,p. 693-697
- https://doi.org/10.1039/p19950000693
Abstract
(S)-1-Phenylethylamine has been used as a chiral auxiliary as well as a nitrogen atom donor in the synthesis of an enantiomeric pair of azetidine-2,4-dicarboxylic acids, the absolute configuration of one of which has been assigned on the basis of the X-ray structure and the known absolute configuration of the (S)-1-phenylethylamine moiety. Chiral auxiliaries of related C2-symmetric azetidines have also been prepared and their propionamides have been asymmetrically alkylated. The stereochemistry of the resulting products was compared with their analogues having different ring sizes.Keywords
This publication has 0 references indexed in Scilit: