Patterns of gene expression during plasmacytoid differentiation of chronic lymphocytic leukaemia cells
- 4 May 1987
- journal article
- Published by Wiley in FEBS Letters
- Vol. 215 (1) , 127-131
- https://doi.org/10.1016/0014-5793(87)80126-6
Abstract
Chronic lymphocytic leukaemia (CLL) cells may be induced to undergo plasmacytoid differentiation in vitro in response to 12-O-tetradecanoyl phorbol acetate (TPA). We show here that plasmacytoid differentiation and the accompanying accumulation of Cμ immunoglobulin mRNA are preceded by a rapid transient increase in the expression of the proto-oncogenes, c-myc and c-fos. In terminally differentiated cells the level of c-fos mRNA returned to the original basal level whilst c-myc expression remained appreciably higher than in undifferentiated CLL cells. These data support a possible role for c-fos and c-myc in the programmed chain of events that occur during terminal differentiation of B-lymphocytesKeywords
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