A MICROMANIPULATIVE STUDY ON THE MIGRATION OF BLOOD CELLS IN FROG CAPILLARIES

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Abstract
Mechanical and chemical irritation of endothelial cells in the mesentery generally causes the capillary to expand locally. The leucocytes, upon contact with the irritated capillary, become adhesive. Those erythrocytes which become attached exhibit no adhesiveness, but are caught in minute, temporary openings in the wall, having been carried there by the outflow of plasma. Upon recovery, the openings close, whereupon the erythrocytes in the openings are either pinched in two, forced back into the blood stream, or into the tissues. With increase of irritation, the adhesion time for leucocytes drops from 24 to 4 minutes, while the migration time remains approximately 1-3 min. until a degree of irritation is reached sufficient to cause extravasation of erythrocytes. Thereafter, the time of diapedesis of both types of cells decreases with increased irritation.

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