Cholinergic link in the histamine-mediated increase in homovanillic acid in the rat striatum
- 1 March 1977
- journal article
- research article
- Published by Springer Nature in Inflammation Research
- Vol. 7 (1) , 27-30
- https://doi.org/10.1007/bf01964877
Abstract
Adminstration of 500 μg of histamine into the lateral brain ventricle of the rat produced a 50% increase in striatal HVA. The DA level remained unchanged. The histaminemediated elevation of HVA was abolished by pre-treatment with the antihistaminic drug — mepyramine. Moreover atropine significantly reduced the histamine-induced increase of HVA. It is concluded that histamine primarily activates cholinergic neurons and that the changes in DA metabolism are a consequence of an increased cholinergic activity.This publication has 33 references indexed in Scilit:
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