Modification of phosphorothioate oligonucleotides yields potent analogs with minimal toxicity for antisense experiments in the CNS

This publication has 42 references indexed in Scilit:

• Intrastriatal and intraventricular injections of oligodeoxynucleotides in the rat brain: tissue penetration, intracellular distribution and c-fos antisense effects
  Molecular Brain Research, 1998
• Kinetic characteristics of Escherichia coli RNase H1: cleavage of various antisense oligonucleotide-RNA duplexes
  Biochemical Journal, 1995
• Oligonucleotide N3'-->P5' phosphoramidates.
  Proceedings of the National Academy of Sciences, 1995
• Phosphorothioate Oligodeoxynucleotides Bind to Basic Fibroblast Growth Factor, Inhibit Its Binding to Cell Surface Receptors, and Remove It from Low Affinity Binding Sites on Extracellular Matrix
  Published by Elsevier ,1995
• Detection of Ribonuclease H-Generated mRNA Fragments in Human Leukemia Cells Following Reversible Membrane Permeabilization in the Presence of Antisense Oligodeoxynucleotides
  Antisense Research and Development, 1995
• Oligodeoxyribonucleotide N3'.fwdarw.P5' Phosphoramidates: synthesis and Hybridization Properties
  Journal of the American Chemical Society, 1994
• Specific inhibition of endogenous neuropeptide Y synthesis in arcuate nucleus by antisense oligonucleotides suppresses feeding behavior and insulin secretion
  Molecular Brain Research, 1994
• Antisense oligonucleotide eliminates in vivo expression of c-fos in mammalian brain
  European Journal of Pharmacology: Molecular Pharmacology, 1992
• Pharmacokinetics, biodistribution, and stability of oligodeoxynucleotide phosphorothioates in mice.
  Proceedings of the National Academy of Sciences, 1991
• Oligodeoxynucleoside phosphorothioate stability in subcellular extracts, culture media, sera and cerebrospinal fluid
  Journal of Biochemical and Biophysical Methods, 1990