The synthesis of heteroaromatic prostacyclin analogues via keto alkyne cyclisation
- 1 January 1987
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Perkin Transactions 1
- No. 8,p. 1825-1831
- https://doi.org/10.1039/p19870001825
Abstract
Keto alkyne cyclisation has been used to prepare tetrahydrobenzo [b] furans (4) and (15) but cyclopenta[b]furans are not available by this procedure. Compound (15) has been converted into benzofuran prostacyclin analogues (5) and (6) by extremely short routes. Conditions are also described for the conversion of the same keto alkynes into tetrahydrobenzo[b]- and cyclopenta[b]- thiophenes and -pyrroles, (7a,b) and (9a,b). Syntheses of thiophene prostacyclin analogues (8a) and (8b) are also discussed.This publication has 5 references indexed in Scilit:
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