Factors influencing renal excretion of foreign organic acids

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Abstract
Renal excretory mechanisms for 16 organic acids (mostly benzoates) were examined by standard renal clearances in the dog to establish their participation in an active secretory system, and to ascertain the factors influencing their simultaneous tubular reabsorption. Active secretion was demonstrated by clearances greater than the glomerular filtration rate and by inhibition of excretion by presumably competitively transported acids, i.e., hippurates. Critical chemical substituents essential for transport could not be identified. For reabsorption by non-ionic diffusion, the relative roles of acidic strength, lipid solubility, and urinary pH are evaluated with emphasis on the variation in the importance of each of these factors.