Continuous-flow chemiluminescence determination of acetaminophen by reduction of cerium(IV)
- 1 January 1989
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in The Analyst
- Vol. 114 (6) , 711-714
- https://doi.org/10.1039/an9891400711
Abstract
A rapid and precise continuous-flow method is described for the determination of acetaminophen (1.00–10.0 µg ml–1) based on the chemiluminescence produced by its reaction with cerium(IV) in acidic solution. When applied to tablets, the method is relatively free from interferences from common excipients and co-existing drugs. The results obtained for the assay of commercial pharmaceutical preparations compared well with those obtained by a reference method and demonstrated good accuracy and precision.Keywords
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