Subinhibitory concentrations of imipenem induce increased resistance to methicillin and imipenem in vitro in methicillin-resistant Staphylococcus aureus
- 1 April 1984
- journal article
- Published by American Society for Microbiology in Antimicrobial Agents and Chemotherapy
- Vol. 25 (4) , 491-493
- https://doi.org/10.1128/aac.25.4.491
Abstract
Methicillin-resistant (MR) Staphylococcus aureus that was susceptible to less than 0.75 micrograms of imipenem per ml demonstrated inducible resistance. MR S. aureus preincubated with 0.05 microgram of imipenem per ml grew in medium with an imipenem concentration of 32 micrograms/ml, and methicillin MICs increased 20-fold. Non-MR S. aureus exhibited no induction. Preincubation with methicillin produced no effect. Induction appeared to be a unique interaction of imipenem with MR S. aureus.Keywords
This publication has 15 references indexed in Scilit:
- In vitro susceptibility patterns of methicillin-resistant and-susceptible Staphylococcus auerues strains in a population of parenteral drug abusers from 1972 to 1981Antimicrobial Agents and Chemotherapy, 1983
- In vitro susceptibility of methicillin-resistant and methicillin-susceptible Staphylococcus aureus strains to N-formimidoyl thienamycinAntimicrobial Agents and Chemotherapy, 1982
- In vitro activity of N-formimidoyl thienamycin and other beta-lactam antibiotics against methicillin-resistant Staphylococcus aureusAntimicrobial Agents and Chemotherapy, 1982
- Comparative in vitro activity of N-formimidoyl thienamycin against gram-positive and gram-negative aerobic and anaerobic species and its beta-lactamase stabilityAntimicrobial Agents and Chemotherapy, 1982
- Temperature Effect on the Susceptibility of Methicillin-Resistant Staphylococcus aureus to Four Different CephalosporinsAntimicrobial Agents and Chemotherapy, 1982
- Antibacterial activities of a new stabilized thienamycin, N-formimidoyl thienamycin, in comparison with other antibioticsAntimicrobial Agents and Chemotherapy, 1980
- Thienamycin, a new .BETA.-lactam antibiotic. I. Discovery, taxonomy, isolation and physical properties.The Journal of Antibiotics, 1979
- Use of a Heavy Inoculum in the In Vitro Evaluation of the Anti-Staphylococcal Activity of 19 CephalosporinsAntimicrobial Agents and Chemotherapy, 1978
- Suppression of Intrinsic Resistance to Methicillin and Other Penicillins in Staphylococcus aureusAntimicrobial Agents and Chemotherapy, 1972
- PENICILLINASE PRODUCTION AND INTRINSIC RESISTANCE TO PENICILLINS IN METHICILLIN-RESISTANT CULTURES OF STAPHYLOCOCCUS AUREUSJournal of Medical Microbiology, 1969