From Marrow to Brain: Expression of Neuronal Phenotypes in Adult Mice
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- 1 December 2000
- journal article
- other
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 290 (5497) , 1775-1779
- https://doi.org/10.1126/science.290.5497.1775
Abstract
After intravascular delivery of genetically marked adult mouse bone marrow into lethally irradiated normal adult hosts, donor-derived cells expressing neuronal proteins (neuronal phenotypes) developed in the central nervous system. Flow cytometry revealed a population of donor-derived cells in the brain with characteristics distinct from bone marrow. Confocal microscopy of individual cells showed that hundreds of marrow-derived cells in brain sections expressed gene products typical of neurons (NeuN, 200-kilodalton neurofilament, and class III β-tubulin) and were able to activate the transcription factor cAMP response element–binding protein (CREB). The generation of neuronal phenotypes in the adult brain 1 to 6 months after an adult bone marrow transplant demonstrates a remarkable plasticity of adult tissues with potential clinical applications.Keywords
This publication has 26 references indexed in Scilit:
- Adult rat and human bone marrow stromal cells differentiate into neuronsJournal of Neuroscience Research, 2000
- Dystrophin expression in the mdx mouse restored by stem cell transplantationNature, 1999
- CREB: A Stimulus-Induced Transcription Factor Activated by A Diverse Array of Extracellular SignalsAnnual Review of Biochemistry, 1999
- Viable offspring derived from fetal and adult mammalian cellsNature, 1997
- Long-Distance Neuronal Migration in the Adult Mammalian BrainScience, 1994
- Expression of differentiated functions in heterokaryons between skeletal myocytes, adrenal cells, fibroblasts and glial cellsExperimental Cell Research, 1984
- Cytoplasmic activation of human nuclear genes in stable heterocaryonsCell, 1983
- Xenogeneic Monoclonal Antibodies to Mouse Lymphoid Differentiation Antigens*Immunological Reviews, 1979
- Monoclonal xenogeneic antibodies to murine cell surface antigens: identification of novel leukocyte differentiation antigensEuropean Journal of Immunology, 1978
- Autoradiographic study of histogenesis in the mouse olfactory bulb I. Time of origin of neurons and neurogliaJournal of Comparative Neurology, 1968