Direct Synthesis of 1,5-Disubstituted-4-magnesio-1,2,3-triazoles, Revisited
Top Cited Papers
- 12 March 2004
- journal article
- research article
- Published by American Chemical Society (ACS) in Organic Letters
- Vol. 6 (8) , 1237-1240
- https://doi.org/10.1021/ol0499203
Abstract
After revisiting earlier works reporting the regioselective synthesis of 1,5-disubstituted-1,2,3-triazoles via the addition of bromomagnesium acetylides to azides, much improved yields of the products were obtained for a wide array of azides and alkynes. The intermediates of that reaction can be trapped with different electrophiles to regioselectively form 1,4,5-trisubstituted 1,2,3-triazoles.Keywords
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