Septum formation, cell division, and sporulation in mutants of yeast deficient in proteinase B.

1 May 1979

journal article
research article
Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences

Vol. 76 (5) , 2395-2399
https://doi.org/10.1073/pnas.76.5.2395

Abstract

Mutants of Saccharomyces cerevisiae that carry lesions in the structural gene for proteinase B [EC 3.4.22.9] prb1, were isolated. Proteinase B was thought to be involved in activation of chitin synthase [EC 2.4.1.16] zymogen to allow septum formation during budding and in sporulation. The prb1 mutants can grow and divide; they form apparently normal septa that contain chitin. Most diploids homozygous for prb1 mutations are unable to complete sporulation.

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