Absorption and transport of ferritin and exogenous horseradish peroxidase in the opisthonephric kidney of the sea lamprey. I. The renal corpuscle

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Abstract
The single, elongate renal corpuscle in the opisthonephros of the sea lamprey deals with exogenous protein tracers in much the same manner as the renal corpuscles in the kidneys of higher vertebrates. Horseradish peroxidase readily diffuses from the capillaries through the mesangium, basement membrane, and slit diaphragms of the visceral epithelium into the urinary space, where it is transported to the tubule. Ferritin diffuses more slowly but follows a similar pathway. Protein tracers which come in contact with the visceral and parietal epithelium, either through diffusion from the circulation or after direct introduction of these substances into the urinary space, are readily absorbed by both types of epithelium. Permeability of the parietal epithelium is suggested by the presence of the tracers in intercellular spaces. The localization of these tracers in the urinary space and epithelial cells both anterior and posterior to the site of their introduction suggests that the elongate glomus is surrounded by a single tortuous urinary space resulting from the continuity of the capsules.

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