INHIBITION OF ADENOSINE-DEAMINASE ACTIVITY RESULTS IN CYTO-TOXICITY TO T-LYMPHOBLASTS INVIVO
- 1 January 1980
- journal article
- research article
- Vol. 56 (3) , 556-559
Abstract
A patient with refractory T cell acute lymphoblastic leukemia was treated with 2''-deoxycoformycin, a potent inhibitor of the enzyme adenosine deaminase. Inhibition of adenosine deaminase activity resulted in the following: an abrupt rise in plasma deoxyadenosine, but not adenosine, concentrations; accumulation of deoxyadenosine triphosphate by lymphoblasts: inhibition of the enzyme S-adenosylhomocysteine hydrolase; and rapid lysis of the leukemic cells. The patient died suddenly 3 days after therapy was discontinued; postmortem examination revealed a complete absence of leukemic cells in all organs. Pharmacologic inhibition of adenosine deaminase activity can result in the lysis of T lymphoblasts in vivo; this effect appears to be mediated by deoxyadenosine.This publication has 9 references indexed in Scilit:
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