Loss of Chromosome 17 loci in prostate cancer detected by polymerase chain reaction quantitation of allelic markers
- 1 August 1995
- journal article
- research article
- Published by Wiley in Genes, Chromosomes and Cancer
- Vol. 13 (4) , 278-284
- https://doi.org/10.1002/gcc.2870130408
Abstract
Using a polymerase chain reaction/microsatellite marker system, we demonstrated that 6 of 22 (27%) clinical stage B (early) primary prostate tumors showed loss of heterozygosity at one or more of five loci on chromosome 17. The sensitivity of this study was increased by use of a Phosphorlmager and statistical analysis of replicate tumor‐normal DNA pairs. Two patients showed tumor‐specific interstitial loss at a locus in close proximity to the familial breast cancer gene BRCAI. These findings suggest that genes on the proximal long arm of chromosome I7 play a pivotal role in the early development of at least a subset of prostatic tumors.Keywords
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