Congenital Heart Disease and Upper-Extremity Deformities

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Abstract
THE familial transmission of congenital heart disease and upper-extremity deformities was first reported by Holt and Oram1 in 1960. Defects of the atrial septum, hand and wrist deformities and frequent bizarre arrhythmias were recorded in members of four successive generations. In 1961 McKusick2 described a second family, a mother and daughter with defects of the atrial septum and hand and wrist deformities. Two years later Zetterqvist3 reported a third family, which included a mother and son with septal defects, cardiac arrhythmias and hand deformities, the mother's deformities being the more severe. A dominant mode of transmission is suggested by the . . .

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