Engagement of ICAM-3 Provides a Costimulatory Signal for Human Immunodeficiency Virus Type 1 Replication in both Activated and Quiescent CD4+T Lymphocytes: Implications for Virus Pathogenesis
Open Access
- 15 June 2004
- journal article
- Published by American Society for Microbiology in Journal of Virology
- Vol. 78 (12) , 6692-6697
- https://doi.org/10.1128/jvi.78.12.6692-6697.2004
Abstract
Human immunodeficiency virus type 1 (HIV-1) replication is regulated by several extracellular signals. We demonstrate that intercellular adhesion molecule 3 (ICAM-3) acts as a costimulating molecule to increase HIV-1 transcription and viral production, a process allowing productive infection of quiescent CD4+ T lymphocytes. The present work suggests an important role for ICAM-3 in HIV-1 replication.Keywords
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