Human Papillomavirus Types 16, 31, and 58 Use Different Endocytosis Pathways To Enter Cells
- 15 March 2003
- journal article
- Published by American Society for Microbiology in Journal of Virology
- Vol. 77 (6) , 3846-3850
- https://doi.org/10.1128/jvi.77.6.3846-3850.2003
Abstract
The early steps of the intracellular trafficking of human papillomavirus type 16 (HPV-16), -31, and -58 pseudovirions were studied by investigating the effects of drugs acting at defined points of endocytosis pathways on virus-like particle-mediated pseudoinfection by overexpression of a dominant-negative form of the Eps15 protein to inhibit clathrin-mediated endocytosis and by electron microscopy. The results obtained suggested the involvement of clathrin-mediated endocytosis in HPV-16 and HPV-58 entry and caveola-mediated endocytosis in HPV-31 entry.Keywords
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