Evaluation of Anti-inflammatory Drugs Based upon the Inhibition of Matrix-Induced Ornithine Decarboxylase Activity during Connective Tissue Proliferation

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Abstract
Summary The ability of several steroidal and nonsteroidal antiinflammatory agents to locally inhibit bone matrix-induced ornithine decarboxylase activity was examined. All of the glucocorticoids tested had an inhibitory effect on ODC activity. The synthetic glucocorticoids dexamethasone, flucinolone acetonide, and betamethasone were most effective in inhibiting ODC activity whereas Cortisol and corticosterone had minimal inhibitory effects. The effects of the glucocorticoids on ODC activity was correlated with their known antiinflammatory potency in other systems. Nonsteroidal drugs had a varying response in this system. Indomethacin and meclofenamic acid were potent inhibitors of ODC activity whereas acetyl salicylic acid, fenoprofane, and noproxane were ineffective in doses examined.