Cerebrospinal Fluid Neuron-Specific Enolase Is Reduced in Alzheimer's Disease
- 1 February 1986
- journal article
- research article
- Published by American Medical Association (AMA) in Archives of Neurology
- Vol. 43 (2) , 153-154
- https://doi.org/10.1001/archneur.1986.00520020047017
Abstract
• Neuron-specific enolase (NSE), a glycolytic enzyme enolase found in brain, was examined in the cerebrospinal fluid and serum of 30 patients with presumptive Alzheimer's disease (AD) and of 13 healthy controls and evaluated as a measure of neuronal functional activity associated with AD. The cerebrospinal fluid NSE levels of patients with AD were significantly reduced and serum NSE levels were significantly increased from controls. Cerebrospinal fluid NSE levels may be representative of central nervous syntem cell loss or a decrease in neuronal functional activity associated with AD.This publication has 13 references indexed in Scilit:
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