Ethanol Induced Dose-Dependent Vasoconstriction in Unanesthetized Lambs
- 1 January 1985
- journal article
- research article
- Published by Taylor & Francis in Experimental Lung Research
- Vol. 9 (3-4) , 341-349
- https://doi.org/10.3109/01902148509057532
Abstract
Low doses of 95% ethanol (.03 ml/kg/min), infused intravenously into chronically instrumented lambs, rapidly caused severe pulmonary vasoconstriction and moderate systemic vaso constriction at low blood alcohol levels. The effect of ethanol was dose dependent. Pulmonary vascular effects of 70% ethanol, but not of 95% ethanol were ameliorated by 100% oxygen. From these data, we speculate that ethanol may have a competitive interaction with the cellular mechanism(s) that transduce oxygen induced pulmonary vasodilation.This publication has 22 references indexed in Scilit:
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