Pathophysiological Characterization of Isolated Diastolic Heart Failure in Comparison to Systolic Heart Failure
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Open Access
- 6 November 2002
- journal article
- research article
- Published by American Medical Association (AMA) in JAMA
- Vol. 288 (17) , 2144-2150
- https://doi.org/10.1001/jama.288.17.2144
Abstract
Congestive heart failure (HF) is a major cause of morbidity and mortality in the United States and is the leading cause of hospitalization in older patients.1 Several epidemiologic studies have recently shown that more than 50% of older patients who present with symptoms of HF have preserved left ventricular (LV) systolic function.1-6 This syndrome has been presumptively termed diastolic heart failure (DHF).2,7-10 However, clinical criteria for HF are not specific. There are other conditions, which are particularly common in elderly patients, that cause similar signs and symptoms. This is further confounded by normal age-related changes in cardiovascular function, the absence of a practical, definitive diastolic function test, and relative lack of information regarding the pathophysiology of DHF. These issues have led to doubts regarding whether patients with DHF have "real" HF11,12 and may have created barriers to progress in characterization and treatment of this important disorder of older patients.8,13,14Keywords
This publication has 1 reference indexed in Scilit:
- Incidence and aetiology of heart failure; a population-based studyEuropean Heart Journal, 1999