Effect of Phenazine di-N-oxide and Phenazine on Total Cellular Dry Mass of Mouse Ehrlich Ascites Cells as Measured by Interference Microscopy2

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Abstract
Eighteen Swiss-Webster mice were inoculated with equal quantities of Ehrlich ascitic fluid and divided into 3 groups of 6 animals each. The first group was untreated as control. The second group was treated with phenazine, a chemical which has little effect on Ehrlich ascites tumor, as a negative control. The third group was treated with phenazine di-N-oxide, a newly reported carcinostatic agent derived from phenazine. Cell samples were taken daily for cellular dry-mass measurements with interference microscopy. All the phenazine di-N-oxide-treated animals responded to the treatment with a quick and progressive increase in cellular dry mass and size and with the number of a certain type of small cells. Two of the animals in the phenazine-treated group showed similar, but much milder, reactions to the treatment. The control group showed no such reaction.