Interference in the Effect of Dexamethasone by Diphenylhydantoin
- 3 July 1969
- journal article
- Published by Massachusetts Medical Society in New England Journal of Medicine
- Vol. 281 (1) , 32-34
- https://doi.org/10.1056/nejm196907032810108
Abstract
INTERACTION between drugs is recognized, currently, as a serious problem in clinical medicine. High on the list of possibilities are interferences between steroid hormonal compounds and various drugs because of the known similarities in their metabolism.1 We first became aware of an inhibitory effect of diphenylhydantoin (DPH) on the action of dexamethasone several years ago during studies in which DPH was evaluated therapeutically for Cushing's syndrome.2 Initially, the interaction was considered unique in this condition, and subsequent observations in other patients demonstrated only a slight interference in the excretion of urinary 17-hydroxycorticosteroids (17-OHCS) during standard dexamethasone suppression tests. More recently, . . .Keywords
This publication has 6 references indexed in Scilit:
- Alteration in the magnitude of induction of tyrosine transaminase by glucocorticoids. The effects of phenobarbital, o,p′DDD and β-diethylaminoethyl diphenylpropylacetate (SKF 525A)Archives of Biochemistry and Biophysics, 1968
- Interference of Heparin Containing Benzyl Alcohol in the Fluorometric Determination of Plasma CorticosteroidsJournal of Clinical Endocrinology & Metabolism, 1967
- INTERMITTENT CUSHING'S SYNDROME WITH ANOMALOUS RESPONSE TO DEXAMETHASONEJournal of Endocrinology, 1966
- Diagnosis of Cushing's SyndromeArchives of internal medicine (1960), 1965
- Effect of Diphenylhydantoin on Cortisol Metabolism in Man *Journal of Clinical Investigation, 1964
- TESTS OF PITUITARY-ADRENAL SUPPRESSIBILITY IN THE DIAGNOSIS OF CUSHING'S SYNDROME*Journal of Clinical Endocrinology & Metabolism, 1960