ARTIFACTS IN RADIOIMMUNOASSAY OF PEPTIDE HORMONES IN GASTRIC AND DUODENAL SECRETIONS

  • 1 January 1976
    • journal article
    • research article
    • Vol. 87  (2) , 292-298
Abstract
Observation of apparently high concentrations of gastrin and insulin in human gastric and duodenal secretions as determined by radioimmunoassay may arise from artifacts caused by proteolytic enzymes. The double-antibody and charcoal separation techniques as commonly employed fail to recognize extensive proteolytic damage to labeled antigen and to antibody.

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