Fluoride Inhibition of DNA Synthesis in Isolated Nuclei from Cultured Cells
- 13 March 2009
- journal article
- research article
- Published by Wiley in Acta Pharmacologica et Toxicologica
- Vol. 45 (4) , 302-305
- https://doi.org/10.1111/j.1600-0773.1979.tb02397.x
Abstract
DNA synthesis in isolated nuclei from both F- sensitive and resistant LS [mouse fibroblast] cells was inhibited by F- at and above 3 mM. These F- concentrations also had an inhibitory effect on DNA synthesis in intact sensitive cells, but not in resistant cells. Due to previous findings that the intracellular F- concentration in the sensitive cells is only 30-40% of the extracellular, it is suggested that inhibition of DNA synthesis in intact cells is secondary to the inhibitory effect on protein synthesis.Keywords
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