PENETRATION OF PHENYLACETIC ACID ACROSS BLOOD-CEREBROSPINAL FLUID BARRIER

  • 1 January 1976
    • journal article
    • research article
    • Vol. 14  (1) , 111-116
Abstract
Labeled phenylacetic acid (14C-PAA) penetrated the blood-CSF barrier in cats only under a high gradient of concentration; under these conditions the administration of large doses of either PAA or probenecid decreased the plasma:CSF 14C-PAA ratio. 14C-PAA was quickly removed from the CSF and blood and was excreted into urine; this excretion was blocked by probenecid. PAA apparently crosses the blood-CSF barrier with difficulty and is secreted by the kidney.

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