CRITICAL INVESTIGATION OF THE RELATION OF THE END-PRODUCTS OF PROTEIN METABOLISM TO ECZEMA AND KINDRED DISORDERS

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Abstract
For many years it has been suggested that hyperuricemia had an etiologic relation to eczema. The earlier assumptions of this association were based wholly, or chiefly, on clinical evidence, but in recent years rather extensive investigation of this question by biochemical methods has resulted in an apparent confirmation of it, or at least has furnished it a certain measure of scientific support. Indeed, it appears from these recent studies that the association of these two conditions is fairly common; at least in that etiologic variety of eczema which is designated endogenous by those who regard eczema as a disease of varied but necessarily of internal origin—a conception to which I do not subscribe. Of course, the association of hyperuricemia and eczema is open to more than one interpretation, and since the question is of importance in the study of the pathogenicity of eczema, there has been no lack of discussion

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